Airway Responsiveness and Changes of Bronchial-wall thickeners in Childhood asthma

Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation.

This review focuses on the methods available for measuring reversible airways obstruction, bronchial hyperresponsiveness (BHR) and inflammation as hallmarks of asthma, and their role in monitoring children with asthma. Persistent bronchial obstruction may occur in asymptomatic children and is considered a risk factor for severe asthma episodes and is associated with poor asthma outcome. Annual ...

Spontaneous changes of airway hyperresponsiveness in bronchial asthma.

RACHIELE et al. [1) reported on stable asthmatics in whom two histamine inhalation tests were carried out on six different days at 8, 16 and 22 h. In seven out of fifteen asthmatic subjects significant diurnal rhythms with a time range of least excitability between 9.8 and 23.1 h could be demonstrated. Diurnal changes of airway responsiveness may, therefore, be important in some patients with b...

Determination the Role of Endothelial Cell-Specific Molecule-1(ESM-1) in Childhood Bronchial Asthma

  Background Endothelial Cell-Specific Molecule-1 (ESM-1) is a 50 kDa soluble proteoglycan that is produced mainly the vascular endothelial cells of the kidney and lung. It is produced by the effects of proangiogenic and pro-inflammatory cytokines, and it indicates activation and dysfunction of the vascular endothelium. We aimed to detect the role of ESM-1 in childre...

Airway wall remodelling in asthma.

Expression of growth factors and remodelling of the airway wall in bronchial asthma.

BACKGROUND Bronchial asthma is characterised by airway structural changes, including mucosal inflammatory infiltration and subepithelial collagen deposition, that may represent the morphological basis for the chronicity of the disease. The relationship between airway wall thickness and growth factors in asthma has not been elucidated. METHODS Bronchial biopsy specimens were obtained from 21 a...